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Article

Epigenetic variation in the serotonin transporter gene predicts resting state functional connectivity strength within the salience-network.

Human brain mapping - 1 Nov 2015

Muehlhan Markus, Kirschbaum Clemens, Wittchen Hans-Ulrich, Alexander Nina

Abstract excerpt

Genetic variation in the serotonin transporter gene (SLC6A4) has been associated with psychopathology and aberrant brain functioning in a plethora of clinical and imaging studies. In contrast, the neurobiological correlates of epigenetic signatures in SLC6A4, such as DNA methylation profiles, have only recently been explored in human brain imaging research. The present study is the first to apply a resting state...

Topics

Adult
Amygdala
Cerebral Cortex
Connectome
CpG Islands
Epigenesis, Genetic
Female
Genotype
Humans
Magnetic Resonance Imaging
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Nerve Net

Promoter Regions, Genetic

Serotonin Plasma Membrane Transport Proteins

Young Adult

Source

Open in PubMed Open full text

Identifiers

PMID: 26303978
DOI: 10.1002/hbm.22923
PMCID: PMC6869056

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-26303978-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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