Expanding the genetic architecture of nicotine dependence and its shared genetics with multiple traits.

doi:10.1038/s41467-020-19265-z

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Article

Expanding the genetic architecture of nicotine dependence and its shared genetics with multiple traits.

Nature communications - 3 Nov 2020

Quach Bryan C, Bray Michael J, Gaddis Nathan C, Liu Mengzhen, Palviainen Teemu, Minica Camelia C, Zellers Stephanie, Sherva Richard, Aliev Fazil, Nothnagel Michael, Young Kendra A, Marks Jesse A, Young Hannah, Carnes Megan U, Guo Yuelong, Waldrop Alex, Sey Nancy Y A, Landi Maria T, McNeil Daniel W, Drichel Dmitriy, Farrer Lindsay A, Markunas Christina A, Vink Jacqueline M, Hottenga Jouke-Jan, Iacono William G, Kranzler Henry R, Saccone Nancy L, Neale Michael C, Madden Pamela, Rietschel Marcella, Marazita Mary L, McGue Matthew, Won Hyejung, Winterer Georg, Grucza Richard, Dick Danielle M, Gelernter Joel, Caporaso Neil E, Baker Timothy B, Boomsma Dorret I, Kaprio Jaakko, Hokanson John E, Vrieze Scott, Bierut Laura J, Johnson Eric O, Hancock Dana B

Abstract excerpt

Cigarette smoking is the leading cause of preventable morbidity and mortality. Genetic variation contributes to initiation, regular smoking, nicotine dependence, and cessation. We present a Fagerström Test for Nicotine Dependence (FTND)-based genome-wide association study in 58,000 European or African ancestry smokers. We observe five genome-wide significant loci, including previously unreported loci MAGI2/GNAI1...

Topics

Genetic Loci
Genetic Predisposition to Disease
Genome-Wide Association Study
Humans
Inheritance Patterns

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Linkage Disequilibrium

Meta-Analysis as Topic

Molecular Sequence Annotation

Phenotype

Polymorphism, Single Nucleotide

Quantitative Trait, Heritable

Tobacco Use Disorder

Source

Open in PubMed Open full text

Identifiers

PMID: 33144568
DOI: 10.1038/s41467-020-19265-z
PMCID: PMC7642344

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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