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Article

The CHRNA5/CHRNA3/CHRNB4 Nicotinic Receptor Regulome: Genomic Architecture, Regulatory Variants, and Clinical Associations.

Human mutation - 1 Jan 2017

Barrie Elizabeth S, Hartmann Katherine, Lee Sung-Ha, Frater John T, Seweryn Michal, Wang Danxin, Sadee Wolfgang

Abstract excerpt

Functionally related genes often cluster into a genome region under coordinated regulation, forming a local regulome. To understand regulation of the CHRNA5/CHRNA3/CHRNB4 nicotinic receptor gene cluster, we integrate large-scale RNA expression data (brain and peripheral) from GTEx (Genotype Tissue Expression), clinical associations (GRASP), and linkage disequilibrium data (1000 Genomes) to find candidate SNPs...

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Source

Open in PubMed Open full text

Identifiers

PMID: 27758088
DOI: 10.1002/humu.23135
PMCID: PMC5154896

Genes

CHRNA5
CHRNA3
CHRNB4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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