Article
Genetic risk for nicotine dependence in the cholinergic system and activation of the brain reward system in healthy adolescents.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Oct 2013
Nees F, Witt S H, Lourdusamy A, Vollstädt-Klein S, Steiner S, Poustka L, Banaschewski T, Barker G J, Büchel C, Conrod P J, Frank J, Gallinat J, Garavan H, Heinz A, Ittermann B, Loth E, Mann K, Artiges E, Paus T, Pausova Z, Smolka M N, Struve M, Schumann G, Rietschel M, Flor H
Abstract excerpt
Genetic variation in a genomic region on chromosome 15q25.1, which encodes the alpha5, alpha3, and beta4 subunits of the cholinergic nicotinic receptor genes, confers risk to smoking and nicotine dependence (ND). Neural reward-related responses have previously been identified as important factors in the development of drug dependence involving ND. Applying an imaging genetics approach in two cohorts (N=487;...
Topics
- Adolescent
- Adolescent Behavior
- Corpus Striatum
- Female
- Frontal Lobe
- Functional Neuroimaging
- Genetic Predisposition to Disease
- Genotype
- Gyrus Cinguli