Article
5-HTTLPR polymorphism impacts human cingulate-amygdala interactions: a genetic susceptibility mechanism for depression.
Nature neuroscience - 1 Jun 2005
Pezawas Lukas, Meyer-Lindenberg Andreas, Drabant Emily M, Verchinski Beth A, Munoz Karen E, Kolachana Bhaskar S, Egan Michael F, Mattay Venkata S, Hariri Ahmad R, Weinberger Daniel R
Abstract excerpt
Carriers of the short allele of a functional 5' promoter polymorphism of the serotonin transporter gene have increased anxiety-related temperamental traits, increased amygdala reactivity and elevated risk of depression. Here, we used multimodal neuroimaging in a large sample of healthy human subjects to elucidate neural mechanisms underlying this complex genetic association. Morphometrical analyses showed reduced...
Topics
- Amygdala
- Anthropometry
- Anxiety Disorders
- Atrophy
- Brain Chemistry
- Brain Mapping
- Depressive Disorder
- Fear
- Genetic Predisposition to Disease
- Gyrus Cinguli
- Humans
- Magnetic Resonance Imaging
- Membrane Glycoproteins