Article

Smoking-informed methylation and expression QTLs in human brain and colocalization with smoking-associated genetic loci

2023-09-19

Abstract excerpt

Smoking is a leading cause of preventable morbidity and mortality. Smoking is heritable, and genome-wide association studies (GWAS) of smoking behaviors have identified hundreds of significant loci. Most GWAS-identified variants are noncoding with unknown neurobiological effects. We used genome-wide genotype, DNA methylation, and RNA sequencing data in postmortem human nucleus accumbens (NAc) to identify cis -meth...

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Literature Corpus work: 7592178f-4b3e-5d14-905e-079e341a8d5e
DOI: 10.1101/2023.09.18.23295431

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