Article
Replication stress checkpoint signaling controls tRNA gene transcription.
Nature structural & molecular biology - 1 Aug 2010
Nguyen Vesna C, Clelland Brett W, Hockman Darren J, Kujat-Choy Sonya L, Mewhort Holly E, Schultz Michael C
Abstract excerpt
In budding yeast, the transcriptional machinery at tRNA genes naturally interferes with replication in a way that can promote chromosome breakage. Here we show that a signaling module composed of core components of the replication stress checkpoint pathway represses this fork-pausing machinery in normally cycling and genotoxin-treated cells. Specifically, the sensor kinase Mec1, the signaling adaptor Mrc1 and the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.