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DNA Damage and Replication Stress Checkpoints

20 Jun 2025

Abstract excerpt

DNA damage checkpoints are key regulatory signaling cascades that arrest cell cycle progression upon DNA damage or upon DNA replication stalling and allow time for repair or correction. Failure to elicit these checkpoints can lead to genomic instability that can result in cell death or mutations, ultimately leading to diseases such as cancer. Components of the DNA damage checkpoint are attractive targets for...

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PMID: 40540755
DOI: 10.1146/annurev-biochem-072324-031915

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