Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mrc1 and Tof1 promote replication fork progression and recovery independently of Rad53.

Molecular cell - 2 Sept 2005

Tourrière Hélène, Versini Gwennaëlle, Cordón-Preciado Violeta, Alabert Constance, Pasero Philippe

Abstract excerpt

The yeast checkpoint factors Mrc1p and Tof1p travel with the replication fork and mediate the activation of the Rad53p kinase in response to a replication stress. We show here that both proteins are required for normal fork progression but play different roles at stalled forks. Tof1p is critical for the activity of the rDNA replication fork barrier (RFB) but plays a minor role in the replication checkpoint. In...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Checkpoint Kinase 2
Share to DNA Replication
Share to DNA, Ribosomal

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Hydroxyurea

Share to Methyl Methanesulfonate

Share to Mutagens

Share to Nucleic Acid Synthesis Inhibitors

Share to S Phase

Source

Identifiers

PMID: 16137625
DOI: 10.1016/j.molcel.2005.07.028

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mrc1 and Tof1 promote replication fork progression and recovery independently of Rad53.PMID 16137625Read ↗

S-phase checkpoint proteins Tof1 and Mrc1 form a stable replication-pausing complex.Semantic proximity Read ↗

Replication checkpoint protein Mrc1 is regulated by Rad3 and Tel1 in fission yeast.Semantic proximity Read ↗

Mrc1 is required for normal progression of replication forks throughout chromatin in S. cerevisiae.Semantic proximity Read ↗

Continued DNA synthesis in replication checkpoint mutants leads to fork collapse.Semantic proximity Read ↗

Mrc1, a non-essential DNA replication protein, is required for telomere end protection following loss of capping by Cdc13, Yku or telomerase.Semantic proximity Read ↗

Mrc1 protects uncapped budding yeast telomeres from exonuclease EXO1.Semantic proximity Read ↗

Rad53 checkpoint kinase regulation of DNA replication fork rate via Mrc1 phosphorylation.Semantic proximity Read ↗

Rhp51-dependent recombination intermediates that do not generate checkpoint signal are accumulated in Schizosaccharomyces pombe rad60 and smc5/6 mutants after release from replication arrest.Semantic proximity Read ↗

Rad53 kinase activation-independent replication checkpoint function of the N-terminal forkhead-associated (FHA1) domain.Semantic proximity Read ↗

A postsynaptic role for Rhp55/57 that is responsible for cell death in Deltarqh1 mutants following replication arrest in Schizosaccharomyces pombe.Semantic proximity Read ↗

Checkpoint-dependent RNR induction promotes fork restart after replicative stress.Semantic proximity Read ↗

Replication stress checkpoint signaling controls tRNA gene transcription.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.