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Article

S-phase checkpoint proteins Tof1 and Mrc1 form a stable replication-pausing complex.

Nature - 28 Aug 2003

Katou Yuki, Kanoh Yutaka, Bando Masashige, Noguchi Hideki, Tanaka Hirokazu, Ashikari Toshihiko, Sugimoto Katsunori, Shirahige Katsuhiko

Abstract excerpt

The checkpoint regulatory mechanism has an important role in maintaining the integrity of the genome. This is particularly important in S phase of the cell cycle, when genomic DNA is most susceptible to various environmental hazards. When chemical agents damage DNA, activation of checkpoint signalling pathways results in a temporary cessation of DNA replication. A replication-pausing complex is believed to be...

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PMID: 12944972
DOI: 10.1038/nature01900

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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