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Article

The Replisome-Coupled E3 Ubiquitin Ligase Rtt101Mms22 Counteracts Mrc1 Function to Tolerate Genotoxic Stress.

PLoS genetics - 1 Feb 2016

Buser Raymond, Kellner Vanessa, Melnik Andre, Wilson-Zbinden Caroline, Schellhaas René, Kastner Lisa, Piwko Wojciech, Dees Martina, Picotti Paola, Maric Marija, Labib Karim, Luke Brian, Peter Matthias

Abstract excerpt

Faithful DNA replication and repair requires the activity of cullin 4-based E3 ubiquitin ligases (CRL4), but the underlying mechanisms remain poorly understood. The budding yeast Cul4 homologue, Rtt101, in complex with the linker Mms1 and the putative substrate adaptor Mms22 promotes progression of replication forks through damaged DNA. Here we characterized the interactome of Mms22 and found that the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26849847
DOI: 10.1371/journal.pgen.1005843
PMCID: PMC4743919

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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