Article
Rpd3L Contributes to the DNA Damage Sensitivity of Saccharomyces cerevisiae Checkpoint Mutants.
Genetics - 1 Feb 2019
Gómez-González Belén, Patel Harshil, Early Anne, Diffley John F X
Abstract excerpt
DNA replication forks that are stalled by DNA damage activate an S-phase checkpoint that prevents irreversible fork arrest and cell death. The increased cell death caused by DNA damage in budding yeast cells lacking the Rad53 checkpoint protein kinase is partially suppressed by deletion of the EXO1 gene. Using a whole-genome sequencing approach, we identified two additional genes, RXT2 and RPH1, whose mutation...
Topics
- DNA Damage
- DNA Replication
- Histone Deacetylase 1
- Histone Deacetylases
- Histone Demethylases
- Mutation
- Repressor Proteins
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins