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Article

DNA-repair scaffolds dampen checkpoint signalling by counteracting the adaptor Rad9.

Nature - 3 Jan 2013

Ohouo Patrice Y, Bastos de Oliveira Francisco M, Liu Yi, Ma Chu Jian, Smolka Marcus B

Abstract excerpt

In response to genotoxic stress, a transient arrest in cell-cycle progression enforced by the DNA-damage checkpoint (DDC) signalling pathway positively contributes to genome maintenance. Because hyperactivated DDC signalling can lead to a persistent and detrimental cell-cycle arrest, cells must tightly regulate the activity of the kinases involved in this pathway. Despite their importance, the mechanisms for...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23160493
DOI: 10.1038/nature11658
PMCID: PMC3536934

Genes

DDC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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