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Mrc1 protects uncapped budding yeast telomeres from exonuclease EXO1.

DNA repair - 1 Nov 2007

Tsolou Avgi, Lydall David

Abstract excerpt

Mrc1 (Mediator of Replication Checkpoint 1) is a component of the DNA replication fork machinery and is necessary for checkpoint activation after replication stress. In this study, we addressed the role of Mrc1 at uncapped telomeres. Our experiments show that Mrc1 contributes to the vitality of both cdc13-1 and yku70Delta telomere capping mutants. Cells with telomere capping defects containing MRC1 or mrc1(AQ), a...

Topics

Cell Cycle
Cell Cycle Proteins
Cyclin B
DNA, Single-Stranded
Exodeoxyribonucleases
Fungal Proteins
Mutation
Saccharomycetales
Telomere

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 17618841
DOI: 10.1016/j.dnarep.2007.05.010
PMCID: PMC2077361

Genes

EXO1
MRC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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Mrc1 protects uncapped budding yeast telomeres from exonuclease EXO1.PMID 17618841Read ↗

Mrc1, a non-essential DNA replication protein, is required for telomere end protection following loss of capping by Cdc13, Yku or telomerase.Semantic proximity Read ↗

Pif1- and Exo1-dependent nucleases coordinate checkpoint activation following telomere uncapping.Semantic proximity Read ↗

Rif1 and Exo1 regulate the genomic instability following telomere losses.Semantic proximity Read ↗

Survival and Growth of Yeast without Telomere Capping by Cdc13 in the Absence of Sgs1, Exo1, and Rad9Semantic proximity Read ↗

MRX protects telomeric DNA at uncapped telomeres of budding yeast cdc13-1 mutants.Semantic proximity Read ↗

Mec1 and Rad53 inhibit formation of single-stranded DNA at telomeres of Saccharomyces cerevisiae cdc13-1 mutants.Semantic proximity Read ↗

Mrc1 is required for normal progression of replication forks throughout chromatin in S. cerevisiae.Semantic proximity Read ↗

Requirement of the Mre11 complex and exonuclease 1 for activation of the Mec1 signaling pathway.Semantic proximity Read ↗

Exo1 and Rad24 differentially regulate generation of ssDNA at telomeres of Saccharomyces cerevisiae cdc13-1 mutants.Semantic proximity Read ↗

Checkpoint-dependent phosphorylation of Exo1 modulates the DNA damage response.Semantic proximity Read ↗

Exonuclease-1 deletion impairs DNA damage signaling and prolongs lifespan of telomere-dysfunctional mice.Semantic proximity Read ↗

A mutation in EXO1 defines separable roles in DNA mismatch repair and post-replication repair.Semantic proximity Read ↗

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