Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Rad53 checkpoint kinase regulation of DNA replication fork rate via Mrc1 phosphorylation.

eLife - 13 Aug 2021

McClure Allison W, Diffley John Fx

Abstract excerpt

The Rad53 DNA checkpoint protein kinase plays multiple roles in the budding yeast cell response to DNA replication stress. Key amongst these is its enigmatic role in safeguarding DNA replication forks. Using DNA replication reactions reconstituted with purified proteins, we show Rad53 phosphorylation of Sld3/7 or Dbf4-dependent kinase blocks replication initiation whilst phosphorylation of Mrc1 or Mcm10 slows...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Cycle Proteins
Share to Checkpoint Kinase 2
Share to DNA Damage

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Replication

Share to Gene Expression Regulation, Fungal

Share to Phosphorylation

Share to Saccharomyces cerevisiae

Share to Saccharomyces cerevisiae Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 34387546
DOI: 10.7554/eLife.69726
PMCID: PMC8387023

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Rad53 checkpoint kinase regulation of DNA replication fork rate via Mrc1 phosphorylation.PMID 34387546Read ↗

Mcm2-7 Is an Active Player in the DNA Replication Checkpoint Signaling Cascade via Proposed Modulation of Its DNA Gate.Semantic proximity Read ↗

Mrc1 is required for normal progression of replication forks throughout chromatin in S. cerevisiae.Semantic proximity Read ↗

Novel role for checkpoint Rad53 protein kinase in the initiation of chromosomal DNA replication in Saccharomyces cerevisiae.Semantic proximity Read ↗

Rad53 limits CMG helicase uncoupling from DNA synthesis at replication forks.Semantic proximity Read ↗

Mec1 is one of multiple kinases that prime the Mcm2-7 helicase for phosphorylation by Cdc7.Semantic proximity Read ↗

Mcm2 phosphorylation and the response to replicative stress.Semantic proximity Read ↗

Mrc1 and DNA polymerase epsilon function together in linking DNA replication and the S phase checkpoint.Semantic proximity Read ↗

Replication checkpoint protein Mrc1 is regulated by Rad3 and Tel1 in fission yeast.Semantic proximity Read ↗

The Replisome-Coupled E3 Ubiquitin Ligase Rtt101Mms22 Counteracts Mrc1 Function to Tolerate Genotoxic Stress.Semantic proximity Read ↗

Mrc1 and Tof1 promote replication fork progression and recovery independently of Rad53.Semantic proximity Read ↗

Replication stress checkpoint signaling controls tRNA gene transcription.Semantic proximity Read ↗

The direct binding of Mrc1, a checkpoint mediator, to Mcm6, a replication helicase, is essential for the replication checkpoint against methyl methanesulfonate-induced stress.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.