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Article

Role of the ubiquitin-binding domain of Polη in Rad18-independent translesion DNA synthesis in human cell extracts.

Nucleic acids research - 1 Oct 2010

Schmutz Valérie, Janel-Bintz Régine, Wagner Jérôme, Biard Denis, Shiomi Naoko, Fuchs Robert P, Cordonnier Agnès M

Abstract excerpt

In eukaryotic cells, the Rad6/Rad18-dependent monoubiquitination of the proliferating cell nuclear antigen (PCNA) plays an essential role in the switching between replication and translesion DNA synthesis (TLS). The DNA polymerase Polη binds to PCNA via a consensus C-terminal PCNA-interacting protein (PIP) motif. It also specifically interacts with monoubiquitinated PCNA thanks to a recently identified...

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Source

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Identifiers

PMID: 20529881
DOI: 10.1093/nar/gkq403
PMCID: PMC2965212

Genes

PCNA
CPD
PIP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Role of the ubiquitin-binding domain of Polη in Rad18-independent translesion DNA synthesis in human cell extracts.PMID 20529881Read ↗

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