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Article

Lysine 63-polyubiquitination guards against translesion synthesis-induced mutations.

PLoS genetics - 1 Jul 2006

Chiu Roland K, Brun Jan, Ramaekers Chantal, Theys Jan, Weng Lin, Lambin Philippe, Gray Douglas A, Wouters Bradly G

Abstract excerpt

Eukaryotic cells possess several mechanisms to protect the integrity of their DNA against damage. These include cell-cycle checkpoints, DNA-repair pathways, and also a distinct DNA damage-tolerance system that allows recovery of replication forks blocked at sites of DNA damage. In both humans and yeast, lesion bypass and restart of DNA synthesis can occur through an error-prone pathway activated following...

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Source

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Identifiers

PMID: 16789823
DOI: 10.1371/journal.pgen.0020116
PMCID: PMC1513265

Genes

PCNA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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