Article
Roles of PCNA ubiquitination and TLS polymerases κ and η in the bypass of methyl methanesulfonate-induced DNA damage.
Nucleic acids research - 1 Jan 2015
Wit Niek, Buoninfante Olimpia Alessandra, van den Berk Paul C M, Jansen Jacob G, Hogenbirk Marc A, de Wind Niels, Jacobs Heinz
Abstract excerpt
Translesion synthesis (TLS) provides a highly conserved mechanism that enables DNA synthesis on a damaged template. TLS is performed by specialized DNA polymerases of which polymerase (Pol) κ is important for the cellular response to DNA damage induced by benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide (BPDE), ultraviolet (UV) light and the alkylating agent methyl methanesulfonate (MMS). As TLS polymerases are...
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