Article
Ubiquitin-binding domains in Y-family polymerases regulate translesion synthesis.
Science (New York, N.Y.) - 16 Dec 2005
Bienko Marzena, Green Catherine M, Crosetto Nicola, Rudolf Fabian, Zapart Grzegorz, Coull Barry, Kannouche Patricia, Wider Gerhard, Peter Matthias, Lehmann Alan R, Hofmann Kay, Dikic Ivan
Abstract excerpt
Translesion synthesis (TLS) is the major pathway by which mammalian cells replicate across DNA lesions. Upon DNA damage, ubiquitination of proliferating cell nuclear antigen (PCNA) induces bypass of the lesion by directing the replication machinery into the TLS pathway. Yet, how this modification...
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