Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Spatiotemporal regulation of PCNA ubiquitination in damage tolerance pathways

3 Sept 2019

Abstract excerpt

DNA is constantly exposed to a wide variety of exogenous and endogenous agents, and most DNA lesions inhibit DNA synthesis. To cope with such problems during replication, cells have molecular mechanisms to resume DNA synthesis in the presence of DNA lesions, which are known as DNA damage tolerance (DDT) pathways. The concept of ubiquitination-mediated regulation of DDT pathways in eukaryotes was established via...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to Carcinogens and Genotoxicity Assessment
Share to DNA Repair Mechanisms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 31736364
DOI: 10.1080/10409238.2019.1687420

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Spatiotemporal regulation of PCNA ubiquitination in damage tolerance pathwaysPMID 31736364Read ↗

DNA damage tolerance: when it's OK to make mistakes.Semantic proximity Read ↗

PCNA Modifications for Regulation of Post-Replication Repair PathwaysSemantic proximity Read ↗

Control of PCNA deubiquitylation in yeast.Semantic proximity Read ↗

Characterization of human Spartan/C1orf124, an ubiquitin-PCNA interacting regulator of DNA damage toleranceSemantic proximity Read ↗

Role of deubiquitinating enzymes in DNA double-strand break repairSemantic proximity Read ↗

Regulation of the DNA damage response by ubiquitin conjugationSemantic proximity Read ↗

Relevance of simultaneous mono-ubiquitinations of multiple units of PCNA homo-trimers in DNA damage tolerance.Semantic proximity Read ↗

The emerging role of deubiquitinating enzymes in genomic integrity, diseases, and therapeuticsSemantic proximity Read ↗

Degradation‐linked ubiquitin signal and proteasome are integral components of DNA double strand break repair: New perspectives for anti‐cancer therapySemantic proximity Read ↗

PCNA Deubiquitylases Control DNA Damage Bypass at Replication Forks.Semantic proximity Read ↗

Control of DNA Replication Initiation by UbiquitinSemantic proximity Read ↗

Constitutive fusion of ubiquitin to PCNA provides DNA damage tolerance independent of translesion polymerase activities.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.