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Article

Constitutive fusion of ubiquitin to PCNA provides DNA damage tolerance independent of translesion polymerase activities.

Nucleic acids research - 1 Aug 2010

Pastushok Landon, Hanna Michelle, Xiao Wei

Abstract excerpt

In response to replication-blocking DNA lesions, proliferating cell nuclear antigen (PCNA) can be conjugated with a single ubiquitin (Ub) or Lys63-linked Ub chains at the Lys164 residue, leading to two modes of DNA damage tolerance (DDT), namely translesion synthesis (TLS) and error-free DDT, respectively. Several reports suggest a model whereby monoubiquitylated PCNA recruits TLS polymerases through an enhanced...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20385585
DOI: 10.1093/nar/gkq239
PMCID: PMC2926605

Genes

PCNA
DDT
RAD18

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Constitutive fusion of ubiquitin to PCNA provides DNA damage tolerance independent of translesion polymerase activities.PMID 20385585Read ↗

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