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Article

DNA-damage tolerance mediated by PCNA*Ub fusions in human cells is dependent on Rev1 but not Polη.

Nucleic acids research - 1 Aug 2013

Qin Zhoushuai, Lu Mengxue, Xu Xin, Hanna Michelle, Shiomi Naoko, Xiao Wei

Abstract excerpt

In response to replication-blocking lesions, proliferating cell nuclear antigen (PCNA) can be sequentially ubiquitinated at the K164 residue, leading to two modes of DNA-damage tolerance, namely, translesion DNA synthesis (TLS) and error-free lesion bypass. Although the majority of reported data support a model whereby monoubiquitinated PCNA enhances its affinity for TLS polymerases and hence recruits them to the...

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Identifiers

PMID: 23761444
DOI: 10.1093/nar/gkt542
PMCID: PMC3753651

Genes

PCNA
RAD18

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