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Article

Relevance of simultaneous mono-ubiquitinations of multiple units of PCNA homo-trimers in DNA damage tolerance.

PloS one - 1 Jan 2015

Kanao Rie, Masuda Yuji, Deguchi Saori, Yumoto-Sugimoto Mayumi, Hanaoka Fumio, Masutani Chikahide

Abstract excerpt

DNA damage tolerance (DDT) pathways, including translesion synthesis (TLS) and additional unknown mechanisms, enable recovery from replication arrest at DNA lesions. DDT pathways are regulated by post-translational modifications of proliferating cell nuclear antigen (PCNA) at its K164 residue. In particular, mono-ubiquitination by the ubiquitin ligase RAD18 is crucial for Polη-mediated TLS. Although the...

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Source

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Identifiers

PMID: 25692884
DOI: 10.1371/journal.pone.0118775
PMCID: PMC4332867

Genes

PCNA
DDT
RAD18
REV1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Relevance of simultaneous mono-ubiquitinations of multiple units of PCNA homo-trimers in DNA damage tolerance.PMID 25692884Read ↗

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