Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Different types of interaction between PCNA and PIP boxes contribute to distinct cellular functions of Y-family DNA polymerases.

Nucleic acids research - 18 Sept 2015

Masuda Yuji, Kanao Rie, Kaji Kentaro, Ohmori Haruo, Hanaoka Fumio, Masutani Chikahide

Abstract excerpt

Translesion DNA synthesis (TLS) by the Y-family DNA polymerases Polη, Polι and Polκ, mediated via interaction with proliferating cell nuclear antigen (PCNA), is a crucial pathway that protects human cells against DNA damage. We report that Polη has three PCNA-interacting protein (PIP) boxes (PIP1, 2, 3) that contribute differentially to two distinct functions, stimulation of DNA synthesis and promotion of PCNA...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Motifs
Share to Cell Line

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA-Directed DNA Polymerase

Share to Mutation

Share to Proliferating Cell Nuclear Antigen

Share to Protein Interaction Domains and Motifs

Share to Ubiquitination

Source

Open in PubMed Open full text

Identifiers

PMID: 26170230
DOI: 10.1093/nar/gkv712
PMCID: PMC4652755

Genes

PCNA
PIP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Different types of interaction between PCNA and PIP boxes contribute to distinct cellular functions of Y-family DNA polymerases.PMID 26170230Read ↗

Ubiquitin-binding domains in Y-family polymerases regulate translesion synthesis.Semantic proximity Read ↗

Identification of two functional PCNA-binding domains in human DNA polymerase κ.Semantic proximity Read ↗

Ubiquitin mediates the physical and functional interaction between human DNA polymerases η and ι.Semantic proximity Read ↗

Role of the ubiquitin-binding domain of Polη in Rad18-independent translesion DNA synthesis in human cell extracts.Semantic proximity Read ↗

Roles of PCNA-binding and ubiquitin-binding domains in human DNA polymerase eta in translesion DNA synthesis.Semantic proximity Read ↗

TRAIP is a PCNA-binding ubiquitin ligase that protects genome stability after replication stressSemantic proximity Read ↗

CHAF1A promotes the translesion DNA synthesis pathway in response to DNA replication stressSemantic proximity Read ↗

Spatiotemporal regulation of PCNA ubiquitination in damage tolerance pathwaysSemantic proximity Read ↗

Complex roles for proliferating cell nuclear antigen in restricting human cytomegalovirus replicationSemantic proximity Read ↗

DNA polymerase lambda directly binds to proliferating cell nuclear antigen through its confined C-terminal region.Semantic proximity Read ↗

Controlling the subcellular localization of DNA polymerases iota and eta via interactions with ubiquitin.Semantic proximity Read ↗

Photo-activatable Ub-PCNA probes reveal new structural features of the Saccharomyces cerevisiae Polη/PCNA complex.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.