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Article

A role for PCNA ubiquitination in immunoglobulin hypermutation.

PLoS biology - 1 Nov 2006

Arakawa Hiroshi, Moldovan George-Lucian, Saribasak Huseyin, Saribasak Nesibe Nur, Jentsch Stefan, Buerstedde Jean-Marie

Abstract excerpt

Proliferating cell nuclear antigen (PCNA) is a DNA polymerase cofactor and regulator of replication-linked functions. Upon DNA damage, yeast and vertebrate PCNA is modified at the conserved lysine K164 by ubiquitin, which mediates error-prone replication across lesions via translesion polymerases. We investigated the role of PCNA ubiquitination in variants of the DT40 B cell line that are mutant in K164 of PCNA...

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Source

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Identifiers

PMID: 17105346
DOI: 10.1371/journal.pbio.0040366
PMCID: PMC1618868

Genes

PCNA

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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