Article
Identification of two functional PCNA-binding domains in human DNA polymerase κ.
Genes to cells : devoted to molecular & cellular mechanisms - 1 Jul 2014
Yoon Jung-Hoon, Acharya Narottam, Park Jeseong, Basu Debashree, Prakash Satya, Prakash Louise
Abstract excerpt
Previously, we have shown that human DNA polymerase (Pol) η has two functional PCNA-binding motifs, PIP1 and PIP2, and that a C-terminal deletion of Polη that lacks the ubiquitin-binding UBZ domain and the PIP2 domain but retains the PIP1 domain promotes normal levels of translesion synthesis (TLS) opposite a cis-syn TT dimer in human cells. Here, we identify two PIP domains in Polκ and show that TLS occurs...
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