Article
A genetic variant BDNF polymorphism alters extinction learning in both mouse and human.
Science (New York, N.Y.) - 12 Feb 2010
Soliman Fatima, Glatt Charles E, Bath Kevin G, Levita Liat, Jones Rebecca M, Pattwell Siobhan S, Jing Deqiang, Tottenham Nim, Amso Dima, Somerville Leah H, Voss Henning U, Glover Gary, Ballon Douglas J, Liston Conor, Teslovich Theresa, Van Kempen Tracey, Lee Francis S, Casey B J
Abstract excerpt
Mouse models are useful for studying genes involved in behavior, but whether they are relevant to human behavior is unclear. Here, we identified parallel phenotypes in mice and humans resulting from a common single-nucleotide polymorphism in the brain-derived neurotrophic factor (BDNF) gene, which is involved in anxiety-related behavior. An inbred genetic knock-in mouse strain expressing the variant BDNF...
Topics
- Adolescent
- Adult
- Alleles
- Amygdala
- Animals
- Brain Mapping
- Brain-Derived Neurotrophic Factor
- Conditioning, Classical
- Cues
- Ethnicity