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Article

Behavioral phenotyping of a rat model of the BDNF Val66Met polymorphism reveals selective impairment of fear memory.

Translational psychiatry - 7 Mar 2022

Jaehne Emily J, Kent Jessica N, Antolasic Emily J, Wright Bradley J, Spiers Jereme G, Creutzberg Kerstin C, De Rosa Federico, Riva Marco A, Sortwell Caryl E, Collier Timothy J, van den Buuse Maarten

Abstract excerpt

The common brain-derived neurotrophic factor (BDNF) Val66Met polymorphism is associated with reduced activity-dependent BDNF release and increased risk for anxiety disorders and PTSD. Here we behaviorally phenotyped a novel Val66Met rat model with an equivalent valine to methionine substitution in the rat Bdnf gene (Val68Met). In a three-day fear conditioning protocol of fear learning and extinction, adult rats...

Topics

Animals
Brain-Derived Neurotrophic Factor
Fear
Female
Genotype
Hippocampus
Polymorphism, Single Nucleotide
Rats

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35256586
DOI: 10.1038/s41398-022-01858-5
PMCID: PMC8901920

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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