BDNF moderates early environmental risk factors for anxiety in mouse.

doi:10.1111/j.1601-183X.2010.00572.x

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Article

BDNF moderates early environmental risk factors for anxiety in mouse.

Genes, brain, and behavior - 1 Jun 2010

Carola Valeria, Gross Cornelius

Abstract excerpt

Anxiety is known to be influenced by both adverse childhood experiences and genetic susceptibility factors. A polymorphism in the brain-derived neurotrophic factor (BDNF) gene modulates the association between adverse early experiences and risk for anxiety and depression in adulthood. An animal model of this gene-by-environment risk factor is lacking. Using two different early environmental manipulations, we...

Topics

Aging
Animals
Anxiety Disorders
Brain Chemistry
Brain-Derived Neurotrophic Factor
Disease Models, Animal
Environment
Female
Genetic Predisposition to Disease
Male
Mice
Mice, Inbred BALB C
Mice, Inbred C57BL
Mice, Knockout
Mutation
Neuronal Plasticity

Source

Open in PubMed

Identifiers

PMID: 20132316
DOI: 10.1111/j.1601-183X.2010.00572.x

Genes

BDNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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