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Article

Impact of genetic variant BDNF (Val66Met) on brain structure and function.

Novartis Foundation symposium - 1 Jan 2008

Chen Zhe-Yu, Bath Kevin, McEwen Bruce, Hempstead Barbara, Lee Francis

Abstract excerpt

A common single-nucleotide polymorphism in the human brain-derived neurotrophic factor (BDNF) gene, a methionine (Met) substitution for valine (Val) at codon 66 (Val66Met), is associated with alterations in brain anatomy and memory, but its relevance to clinical disorders is unclear. We generated a variant BDNF mouse (BDNF(MET/Met)) that reproduces the phenotypic hallmarks in humans with the variant allele....

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Source

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Identifiers

PMID: 18497103
DOI: 10.1002/9780470751251.ch14
PMCID: PMC2735856

Genes

BDNF
MET

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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