Article
Impact of genetic variant BDNF (Val66Met) on brain structure and function.
Novartis Foundation symposium - 1 Jan 2008
Chen Zhe-Yu, Bath Kevin, McEwen Bruce, Hempstead Barbara, Lee Francis
Abstract excerpt
A common single-nucleotide polymorphism in the human brain-derived neurotrophic factor (BDNF) gene, a methionine (Met) substitution for valine (Val) at codon 66 (Val66Met), is associated with alterations in brain anatomy and memory, but its relevance to clinical disorders is unclear. We generated a variant BDNF mouse (BDNF(MET/Met)) that reproduces the phenotypic hallmarks in humans with the variant allele....
Topics
- Amino Acid Substitution
- Animals
- Anxiety Disorders
- Brain
- Brain-Derived Neurotrophic Factor
- Depressive Disorder
- Genetic Predisposition to Disease
- Genetic Variation
- Growth Substances
- Humans
- Mental Disorders
- Methionine
- Mice
- Mice, Transgenic
- Polymorphism, Single Nucleotide
- Psychotic Disorders
- Valine