Article
Variant brain-derived neurotrophic factor Val66Met endophenotypes: implications for posttraumatic stress disorder.
Annals of the New York Academy of Sciences - 1 Oct 2010
Frielingsdorf Helena, Bath Kevin G, Soliman Fatima, Difede JoAnn, Casey B J, Lee Francis S
Abstract excerpt
Recently, a common single nucleotide polymorphism (SNP) has been identified in the gene encoding brain-derived neurotrophic factor (BDNF). The variant BDNF(Met) has been shown to have decreased activity-dependent BDNF secretion from neurons and to lead to impairments in specific forms of learning and altered susceptibility to stress. A mouse model containing BDNF(Met) has also been linked to increased...
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