An ancient polymorphic regulatory region within the BDNF gene associated with obesity modulates anxiety-like behaviour in mice and humans.

doi:10.1038/s41380-023-02359-7

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Article

An ancient polymorphic regulatory region within the BDNF gene associated with obesity modulates anxiety-like behaviour in mice and humans.

Molecular psychiatry - 1 Mar 2024

McEwan Andrew R, Hing Benjamin, Erickson Johanna C, Hutchings Greg, Urama Charity, Norton-Hughes Emily, D'Ippolito Mariam, Berry Susan, Delibegovic Mirela, Grassmann Felix, MacKenzie Alasdair

Abstract excerpt

Obesity and anxiety are morbidities notable for their increased impact on society during the recent COVID-19 pandemic. Understanding the mechanisms governing susceptibility to these conditions will increase our quality of life and resilience to future pandemics. In the current study, we explored the function of a highly conserved regulatory region (BE5.1) within the BDNF gene that harbours a polymorphism strongly...

Topics

Animals
Brain-Derived Neurotrophic Factor
Anxiety
Humans
Mice
Obesity
Female
Male
Polymorphism, Single Nucleotide
Regulatory Sequences, Nucleic Acid

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Inbred C57BL

COVID-19

Alleles

Hypothalamus

Genome-Wide Association Study

Behavior, Animal

Amygdala

Genetic Predisposition to Disease

Source

Open in PubMed Open full text

Identifiers

PMID: 38228888
DOI: 10.1038/s41380-023-02359-7
PMCID: PMC11153140

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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