Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

An ancient polymorphic regulatory region within the BDNF gene associated with obesity modulates anxiety-like behaviour in mice and humans.

Molecular psychiatry - 1 Mar 2024

McEwan Andrew R, Hing Benjamin, Erickson Johanna C, Hutchings Greg, Urama Charity, Norton-Hughes Emily, D'Ippolito Mariam, Berry Susan, Delibegovic Mirela, Grassmann Felix, MacKenzie Alasdair

Abstract excerpt

Obesity and anxiety are morbidities notable for their increased impact on society during the recent COVID-19 pandemic. Understanding the mechanisms governing susceptibility to these conditions will increase our quality of life and resilience to future pandemics. In the current study, we explored the function of a highly conserved regulatory region (BE5.1) within the BDNF gene that harbours a polymorphism strongly...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amygdala
Share to Anxiety

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Behavior, Animal

Share to Brain-Derived Neurotrophic Factor

Share to COVID-19

Share to Hypothalamus

Share to Obesity

Share to Regulatory Sequences, Nucleic Acid

Source

Open in PubMed Open full text

Identifiers

PMID: 38228888
DOI: 10.1038/s41380-023-02359-7
PMCID: PMC11153140

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

An ancient polymorphic regulatory region within the BDNF gene associated with obesity modulates anxiety-like behaviour in mice and humans.PMID 38228888Read ↗

An ancient polymorphic regulatory region within the BDNF gene associated with obesity modulates anxiety-like behaviour in mice and humansSemantic proximity Read ↗

An ancient polymorphic regulatory region within the BDNF gene associated with obesity modulates anxiety-like behaviour in mice and humansSemantic proximity Read ↗

A genetic variant BDNF polymorphism alters extinction learning in both mouse and human.Semantic proximity Read ↗

A Rare Potential Pathogenic Variant in the BDNF Gene is Found in a Brazilian Patient with Severe Childhood-Onset ObesitySemantic proximity Read ↗

Anxiety induced by extra-hypothalamic BDNF deficiency instigates resistance to diet-induced obesitySemantic proximity Read ↗

The BDNF Val66Met polymorphism and anxiety: support for animal knock-in studies from a genetic association study in humans.Semantic proximity Read ↗

Rare Syndromes and Common Variants of the Brain-Derived Neurotrophic Factor Gene in Human Obesity.Semantic proximity Read ↗

Associations of BDNF/BDNF-AS SNPs with Depression, Schizophrenia, and Bipolar DisorderSemantic proximity Read ↗

Screening for genetic variants in BDNF that contribute to childhood obesity.Semantic proximity Read ↗

Variant brain-derived neurotrophic factor (Valine66Methionine) polymorphism contributes to developmental and estrous stage-specific expression of anxiety-like behavior in female mice.Semantic proximity Read ↗

BDNF variant linked to anxiety-related behaviors.Semantic proximity Read ↗

BDNF-Val66Met variant and adolescent stress interact to promote susceptibility to anorexic behavior in mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.