Enhanced extinction of cocaine seeking in brain-derived neurotrophic factor Val66Met knock-in mice.

doi:10.1111/j.1460-9568.2012.08021.x

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Article

Enhanced extinction of cocaine seeking in brain-derived neurotrophic factor Val66Met knock-in mice.

The European journal of neuroscience - 1 Mar 2012

Briand Lisa A, Lee Francis S, Blendy Julie A, Pierce R Christopher

Abstract excerpt

The Val66Met polymorphism in the brain-derived neurotropic factor (BDNF) gene results in alterations in fear extinction behavior in both human populations and mouse models. However, it is not clear whether this polymorphism plays a similar role in extinction of appetitive behaviors. Therefore, we examined operant learning and extinction of both food and cocaine self-administration behavior in an inbred genetic...

Topics

Animals
Behavior, Animal
Brain-Derived Neurotrophic Factor
Cocaine-Related Disorders
Drug-Seeking Behavior
Extinction, Psychological
Gene Knock-In Techniques
Mice
Mice, Inbred C57BL
Polymorphism, Single Nucleotide

Source

Open in PubMed Open full text

Identifiers

PMID: 22394056
DOI: 10.1111/j.1460-9568.2012.08021.x
PMCID: PMC3626276

Genes

BDNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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