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Article

Genetic variant BDNF (Val66Met) polymorphism alters anxiety-related behavior.

Science (New York, N.Y.) - 6 Oct 2006

Chen Zhe-Yu, Jing Deqiang, Bath Kevin G, Ieraci Alessandro, Khan Tanvir, Siao Chia-Jen, Herrera Daniel G, Toth Miklos, Yang Chingwen, McEwen Bruce S, Hempstead Barbara L, Lee Francis S

Abstract excerpt

A common single-nucleotide polymorphism in the brain-derived neurotrophic factor (BDNF) gene, a methionine (Met) substitution for valine (Val) at codon 66 (Val66Met), is associated with alterations in brain anatomy and memory, but its relevance to clinical disorders is unclear. We generated a variant BDNF mouse (BDNF(Met/Met)) that reproduces the phenotypic hallmarks in humans with the variant allele. BDNF(Met)...

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Source

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Identifiers

PMID: 17023662
DOI: 10.1126/science.1129663
PMCID: PMC1880880

Genes

BDNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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