Genetic variant BDNF (Val66Met) polymorphism alters anxiety-related behavior.

doi:10.1126/science.1129663

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Article

Genetic variant BDNF (Val66Met) polymorphism alters anxiety-related behavior.

Science (New York, N.Y.) - 6 Oct 2006

Chen Zhe-Yu, Jing Deqiang, Bath Kevin G, Ieraci Alessandro, Khan Tanvir, Siao Chia-Jen, Herrera Daniel G, Toth Miklos, Yang Chingwen, McEwen Bruce S, Hempstead Barbara L, Lee Francis S

Abstract excerpt

A common single-nucleotide polymorphism in the brain-derived neurotrophic factor (BDNF) gene, a methionine (Met) substitution for valine (Val) at codon 66 (Val66Met), is associated with alterations in brain anatomy and memory, but its relevance to clinical disorders is unclear. We generated a variant BDNF mouse (BDNF(Met/Met)) that reproduces the phenotypic hallmarks in humans with the variant allele. BDNF(Met)...

Topics

Alleles
Animals
Anxiety
Behavior, Animal
Brain-Derived Neurotrophic Factor
Conditioning, Psychological
Dendrites
Dentate Gyrus
Fear
Fluoxetine
Hippocampus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Memory

Mice

Mice, Inbred C57BL

Mice, Transgenic

Motor Activity

Neurons

Organ Size

Source

Open in PubMed Open full text

Identifiers

PMID: 17023662
DOI: 10.1126/science.1129663
PMCID: PMC1880880

Genes

BDNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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