BDNF modulates contextual fear learning during adolescence.

doi:10.1159/000358824

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Article

BDNF modulates contextual fear learning during adolescence.

Developmental neuroscience - 1 Jan 2014

Dincheva Iva, Pattwell Siobhan S, Tessarollo Lino, Bath Kevin G, Lee Francis S

Abstract excerpt

Brain-derived neurotrophic factor (BDNF) is a growth factor that plays key roles in regulating higher-order emotional and cognitive processes including fear learning and memory. A common single-nucleotide polymorphism (SNP) has been identified in the human BDNF gene (BDNF Val66Met) that leads to decreased BDNF secretion and impairments in specific forms of fear learning in adult humans and genetically modified...

Topics

Aging
Animals
Brain-Derived Neurotrophic Factor
Fear
Glyceraldehyde-3-Phosphate Dehydrogenases
Hippocampus
Learning
Male
Mice
Mice, Knockout
Polymorphism, Single Nucleotide
Receptor, trkB

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Identifiers

PMID: 24992985
DOI: 10.1159/000358824
PMCID: PMC4150737

Genes

BDNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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