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Impaired fear memory in a rat model of the brain-derived neurotrophic factor Val66Met polymorphism is reversed by chronic exercise.

Neurobiology of learning and memory - 1 Sept 2023

Jaehne Emily J, Antolasic Emily J, Creutzberg Kerstin C, Begni Veronica, Riva Marco A, van den Buuse Maarten

Abstract excerpt

The brain-derived neurotrophic factor (BDNF) Val66Met polymorphism is associated with reduced activity-dependent BDNF release in the brain and has been implicated in fear and anxiety disorders, including post-traumatic stress disorder. Exercise has been shown to have benefits in affective disorders but the role of BDNF Val66Met remains unclear. Male and female BDNF Val66Met rats were housed in automated...

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Identifiers

PMID: 37269900
DOI: 10.1016/j.nlm.2023.107779

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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