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Article

Structural insight into the membrane insertion of tail-anchored proteins by Get3.

Genes to cells : devoted to molecular & cellular mechanisms - 1 Jan 2010

Yamagata Atsushi, Mimura Hisatoshi, Sato Yusuke, Yamashita Masami, Yoshikawa Azusa, Fukai Shuya

Abstract excerpt

Tail anchored (TA) proteins, which are important for numerous cellular processes, are defined by a single transmembrane domain (TMD) near the C-terminus. The membrane insertion of TA proteins is mediated by the highly conserved ATPase Get3. Here we report the crystal structures of Get3 in ADP-bound and nucleotide-free forms at 3.0 A and 2.8 A resolutions, respectively. Get3 consists of a nucleotide binding domain...

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Identifiers

PMID: 20015340
DOI: 10.1111/j.1365-2443.2009.01362.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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