Article
Ribosome-bound Get4/5 facilitates the capture of tail-anchored proteins by Sgt2 in yeast.
Nature communications - 4 Feb 2021
Zhang Ying, De Laurentiis Evelina, Bohnsack Katherine E, Wahlig Mascha, Ranjan Namit, Gruseck Simon, Hackert Philipp, Wölfle Tina, Rodnina Marina V, Schwappach Blanche, Rospert Sabine
Abstract excerpt
The guided entry of tail-anchored proteins (GET) pathway assists in the posttranslational delivery of tail-anchored proteins, containing a single C-terminal transmembrane domain, to the ER. Here we uncover how the yeast GET pathway component Get4/5 facilitates capture of tail-anchored proteins by Sgt2, which interacts with tail-anchors and hands them over to the targeting component Get3. Get4/5 binds directly and...
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