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Article

The ER membrane complex (EMC) can functionally replace the Oxa1 insertase in mitochondria.

PLoS biology - 1 Mar 2022

Güngör Büsra, Flohr Tamara, Garg Sriram G, Herrmann Johannes M

Abstract excerpt

Two multisubunit protein complexes for membrane protein insertion were recently identified in the endoplasmic reticulum (ER): the guided entry of tail anchor proteins (GET) complex and ER membrane complex (EMC). The structures of both of their hydrophobic core subunits, which are required for the insertion reaction, revealed an overall similarity to the YidC/Oxa1/Alb3 family members found in bacteria,...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 35231030
DOI: 10.1371/journal.pbio.3001380
PMCID: PMC8887752

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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