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Article

The conserved ATPase Get3/Arr4 modulates the activity of membrane-associated proteins in Saccharomyces cerevisiae.

Genetics - 1 Sept 2006

Auld Kathryn L, Hitchcock Amy L, Doherty Hugh K, Frietze Seth, Huang Linda S, Silver Pamela A

Abstract excerpt

The regulation of cellular membrane dynamics is crucial for maintaining proper cell growth and division. The Cdc48-Npl4-Ufd1 complex is required for several regulated membrane-associated processes as part of the ubiquitin-proteasome system, including ER-associated degradation and the control of lipid composition in yeast. In this study we report the results of a genetic screen in Saccharomyces cerevisiae for...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 16816426
DOI: 10.1534/genetics.106.058362
PMCID: PMC1569774

Genes

GET3
GET1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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The conserved ATPase Get3/Arr4 modulates the activity of membrane-associated proteins in Saccharomyces cerevisiae.PMID 16816426Read ↗

Model for eukaryotic tail-anchored protein binding based on the structure of Get3.Semantic proximity Read ↗

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Structural insight into the membrane insertion of tail-anchored proteins by Get3.Semantic proximity Read ↗

Endoplasmic reticulum membrane receptors of the GET pathway are conserved throughout eukaryotes.Semantic proximity Read ↗

The GET System Inserts the Tail-Anchored Protein, SYP72, into Endoplasmic Reticulum Membranes.Semantic proximity Read ↗

Mutations in GET4 disrupt the transmembrane domain recognition complex pathway.Semantic proximity Read ↗

Multicopy suppressor analysis of thermosensitive YIP1 alleles implicates GOT1 in transport from the ER.Semantic proximity Read ↗

The Get1/2 transmembrane complex is an endoplasmic-reticulum membrane protein insertase.Semantic proximity Read ↗

WRB and CAML are necessary and sufficient to mediate tail-anchored protein targeting to the ER membrane.Semantic proximity Read ↗

Studies of mutations of assembly factor Hit1 in budding yeast suggest translation defects as the molecular basis for PEHO syndrome.Semantic proximity Read ↗

Dsl1p, Tip20p, and the novel Dsl3(Sec39) protein are required for the stability of the Q/t-SNARE complex at the endoplasmic reticulum in yeast.Semantic proximity Read ↗

Cooperative and independent activities of Sgt2 and Get5 in the targeting of tail-anchored proteins.Semantic proximity Read ↗

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