Article
Dissecting the molecular organization of the translocon-associated protein complex.
Nature communications - 20 Feb 2017
Pfeffer Stefan, Dudek Johanna, Schaffer Miroslava, Ng Bobby G, Albert Sahradha, Plitzko Jürgen M, Baumeister Wolfgang, Zimmermann Richard, Freeze Hudson H, Engel Benjamin D, Förster Friedrich
Abstract excerpt
In eukaryotic cells, one-third of all proteins must be transported across or inserted into the endoplasmic reticulum (ER) membrane by the ER protein translocon. The translocon-associated protein (TRAP) complex is an integral component of the translocon, assisting the Sec61 protein-conducting channel by regulating signal sequence and transmembrane helix insertion in a substrate-dependent manner. Here we use...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.