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Article

The Get1/2 transmembrane complex is an endoplasmic-reticulum membrane protein insertase.

Nature - 28 Aug 2014

Wang Fei, Chan Charlene, Weir Nicholas R, Denic Vladimir

Abstract excerpt

Hundreds of tail-anchored proteins, including soluble N-ethylmaleimide-sensitive factor attachment receptors (SNAREs) involved in vesicle fusion, are inserted post-translationally into the endoplasmic reticulum membrane by a dedicated protein-targeting pathway. Before insertion, the carboxy-terminal transmembrane domains of tail-anchored proteins are shielded in the cytosol by the conserved targeting factor Get3...

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Share to Adaptor Proteins, Vesicular Transport
Share to Adenosine Triphosphatases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Endoplasmic Reticulum

Share to Guanine Nucleotide Exchange Factors

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Source

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Identifiers

PMID: 25043001
DOI: 10.1038/nature13471
PMCID: PMC4342754

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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The Get1/2 transmembrane complex is an endoplasmic-reticulum membrane protein insertase.PMID 25043001Read ↗

Subunit cooperation in the Get1/2 receptor promotes tail-anchored membrane protein insertion.Semantic proximity Read ↗

A chaperone cascade sorts proteins for posttranslational membrane insertion into the endoplasmic reticulum.Semantic proximity Read ↗

Ribosome-bound Get4/5 facilitates the capture of tail-anchored proteins by Sgt2 in yeast.Semantic proximity Read ↗

Endoplasmic reticulum membrane receptors of the GET pathway are conserved throughout eukaryotes.Semantic proximity Read ↗

Structural characterization of the Get4/Get5 complex and its interaction with Get3.Semantic proximity Read ↗

Model for eukaryotic tail-anchored protein binding based on the structure of Get3.Semantic proximity Read ↗

Mutations in GET4 disrupt the transmembrane domain recognition complex pathway.Semantic proximity Read ↗

WRB and CAML are necessary and sufficient to mediate tail-anchored protein targeting to the ER membrane.Semantic proximity Read ↗

Structural insight into the membrane insertion of tail-anchored proteins by Get3.Semantic proximity Read ↗

A conserved Guided Entry of Tail-anchored pathway is involved in the trafficking of tail-anchored membrane proteins in <i>Plasmodium falciparum</i>Semantic proximity Read ↗

Role of a holo-insertase complex in the biogenesis of biophysically diverse ER membrane proteinsSemantic proximity Read ↗

The GET System Inserts the Tail-Anchored Protein, SYP72, into Endoplasmic Reticulum Membranes.Semantic proximity Read ↗

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