Article
Cooperative and independent activities of Sgt2 and Get5 in the targeting of tail-anchored proteins.
Biological chemistry - 1 Jul 2011
Kohl Christian, Tessarz Peter, von der Malsburg Karina, Zahn Regina, Bukau Bernd, Mogk Axel
Abstract excerpt
Abstract TPR proteins modulate the activity of molecular chaperones. Here, we describe the S. cerevisiae TPR protein Sgt2 as interaction partner of Ssa1 and Hsp104 and as a component of the GET pathway by interacting with Get5. The GET pathway mediates the sorting of tail-anchored (TA) proteins, harboring a C-terminal trans-membrane segment, to the ER membrane. S. cerevisiae sgt2Δ cells show partial defects in TA...
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