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Article

Endoplasmic reticulum membrane receptors of the GET pathway are conserved throughout eukaryotes.

Proceedings of the National Academy of Sciences of the United States of America - 5 Jan 2021

Asseck Lisa Yasmin, Mehlhorn Dietmar Gerald, Monroy Jhon Rivera, Ricardi Martiniano Maria, Breuninger Holger, Wallmeroth Niklas, Berendzen Kenneth Wayne, Nowrousian Minou, Xing Shuping, Schwappach Blanche, Bayer Martin, Grefen Christopher

Abstract excerpt

Type II tail-anchored (TA) membrane proteins are involved in diverse cellular processes, including protein translocation, vesicle trafficking, and apoptosis. They are characterized by a single C-terminal transmembrane domain that mediates posttranslational targeting and insertion into the endoplasmic reticulum (ER) via the Guided-Entry of TA proteins (GET) pathway. The GET system was originally described in...

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Identifiers

PMID: 33443185
DOI: 10.1073/pnas.2017636118
PMCID: PMC7817167

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Endoplasmic reticulum membrane receptors of the GET pathway are conserved throughout eukaryotes.PMID 33443185Read ↗

The GET System Inserts the Tail-Anchored Protein, SYP72, into Endoplasmic Reticulum Membranes.Semantic proximity Read ↗

The Get1/2 transmembrane complex is an endoplasmic-reticulum membrane protein insertase.Semantic proximity Read ↗

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Ribosome-bound Get4/5 facilitates the capture of tail-anchored proteins by Sgt2 in yeast.Semantic proximity Read ↗

WRB and CAML are necessary and sufficient to mediate tail-anchored protein targeting to the ER membrane.Semantic proximity Read ↗

A chaperone cascade sorts proteins for posttranslational membrane insertion into the endoplasmic reticulum.Semantic proximity Read ↗

Structural characterization of the Get4/Get5 complex and its interaction with Get3.Semantic proximity Read ↗

Mutations in GET4 disrupt the transmembrane domain recognition complex pathway.Semantic proximity Read ↗

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Targeting and translocation of proteins to the endoplasmic reticulum at a glanceSemantic proximity Read ↗

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