Article
Subunit cooperation in the Get1/2 receptor promotes tail-anchored membrane protein insertion.
The Journal of cell biology - 1 Nov 2021
Chio Un Seng, Liu Yumeng, Chung SangYoon, Shim Woo Jun, Chandrasekar Sowmya, Weiss Shimon, Shan Shu-Ou
Abstract excerpt
The guided entry of tail-anchored protein (GET) pathway, in which the Get3 ATPase delivers an essential class of tail-anchored membrane proteins (TAs) to the Get1/2 receptor at the endoplasmic reticulum, provides a conserved mechanism for TA biogenesis in eukaryotic cells. The membrane-associated events of this pathway remain poorly understood. Here we show that complex assembly between the cytosolic domains...
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