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Article

GGA autoinhibition revisited.

Traffic (Copenhagen, Denmark) - 1 Feb 2010

Cramer Jacob F, Gustafsen Camilla, Behrens Manja A, Oliveira Cristiano L P, Pedersen Jan Skov, Madsen Peder, Petersen Claus Munck, Thirup Søren S

Abstract excerpt

The cytosolic adaptors GGA1-3 mediate sorting of transmembrane proteins displaying a C-terminal acidic dileucine motif (DXXLL) in their cytosolic domain. GGA1 and GGA3 contain similar but intrinsic motifs that are believed to serve as autoinhibitory sites activated by the phosphorylation of a serine positioned three residues upstream of the DXXLL motif. In the present study, we have subjected the widely...

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Source

Identifiers

PMID: 20015111
DOI: 10.1111/j.1600-0854.2009.01017.x

Genes

GGA1
GGA3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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