Article
Epidermal growth factor-dependent phosphorylation of the GGA3 adaptor protein regulates its recruitment to membranes.
Molecular and cellular biology - 1 Sept 2005
Kametaka Satoshi, Mattera Rafael, Bonifacino Juan S
Abstract excerpt
The Golgi-localized, Gamma-ear-containing, Arf-binding (GGA) proteins are monomeric clathrin adaptors that mediate the sorting of transmembrane cargo at the trans-Golgi network and endosomes. Here we report that one of these proteins, GGA3, becomes transiently phosphorylated upon activation of the epidermal growth factor (EGF) receptor. This phosphorylation takes place on a previously unrecognized site in the...
Topics
- ADP-Ribosylation Factors
- Adaptor Proteins, Vesicular Transport
- Amino Acid Sequence
- Cells, Cultured
- ErbB Receptors
- Humans
- Intracellular Membranes
- Mitogen-Activated Protein Kinases
- Molecular Sequence Data
- Mutation
- Phosphoinositide-3 Kinase Inhibitors
- Phosphorylation
- Protein Transport
- Signal Transduction