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Article

Epidermal growth factor-dependent phosphorylation of the GGA3 adaptor protein regulates its recruitment to membranes.

Molecular and cellular biology - 1 Sept 2005

Kametaka Satoshi, Mattera Rafael, Bonifacino Juan S

Abstract excerpt

The Golgi-localized, Gamma-ear-containing, Arf-binding (GGA) proteins are monomeric clathrin adaptors that mediate the sorting of transmembrane cargo at the trans-Golgi network and endosomes. Here we report that one of these proteins, GGA3, becomes transiently phosphorylated upon activation of the epidermal growth factor (EGF) receptor. This phosphorylation takes place on a previously unrecognized site in the...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 16135791
DOI: 10.1128/MCB.25.18.7988-8000.2005
PMCID: PMC1234315

Genes

GGA3
EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Epidermal growth factor-dependent phosphorylation of the GGA3 adaptor protein regulates its recruitment to membranes.PMID 16135791Read ↗

Phosphorylation-induced conformational changes regulate GGAs 1 and 3 function at the trans-Golgi network.Semantic proximity Read ↗

Multiple phosphorylation events regulate the subcellular localization of GGA1.Semantic proximity Read ↗

GGA1 interacts with the adaptor protein AP-1 through a WNSF sequence in its hinge region.Semantic proximity Read ↗

The acidic cluster of the CK2 site of the cation-dependent mannose 6-phosphate receptor (CD-MPR) but not its phosphorylation is required for GGA1 and AP-1 binding.Semantic proximity Read ↗

Specific regulation of the adaptor protein complex AP-3 by the Arf GAP AGAP1.Semantic proximity Read ↗

ADP-Ribosylation factor 1 (ARF1) regulates recruitment of the AP-3 adaptor complex to membranes.Semantic proximity Read ↗

GGAs: a family of ADP ribosylation factor-binding proteins related to adaptors and associated with the Golgi complex.Semantic proximity Read ↗

Cooperation of GGAs and AP-1 in packaging MPRs at the trans-Golgi network.Semantic proximity Read ↗

Binding of GGA2 to the lysosomal enzyme sorting motif of the mannose 6-phosphate receptor.Semantic proximity Read ↗

Discrete determinants in ArfGAP2/3 conferring Golgi localization and regulation by the COPI coat.Semantic proximity Read ↗

Phosphoinositide-mediated clathrin adaptor progression at the trans-Golgi network.Semantic proximity Read ↗

Golgi-localized, gamma-ear-containing, Arf-binding protein adaptors mediate insulin-responsive trafficking of glucose transporter 4 in 3T3-L1 adipocytes.Semantic proximity Read ↗

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