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Article

The acidic cluster of the CK2 site of the cation-dependent mannose 6-phosphate receptor (CD-MPR) but not its phosphorylation is required for GGA1 and AP-1 binding.

The Journal of biological chemistry - 28 May 2004

Stöckli Jacqueline, Höning Stefan, Rohrer Jack

Abstract excerpt

Lysosomal biogenesis depends on proper transport of lysosomal enzymes by the cation-dependent mannose 6-phosphate receptor (CD-MPR) from the trans-Golgi network (TGN) to endosomes. Trafficking of the CDMPR is mediated by sorting signals in its cytoplasmic tail. GGA1 (Golgi-localizing, gamma-ear-containing, ARF-binding protein-1) binds to CD-MPR in the TGN and targets the receptor to clathrin-coated pits for...

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Share to Adaptor Proteins, Vesicular Transport
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15044437
DOI: 10.1074/jbc.M313525200

Genes

GGA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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The acidic cluster of the CK2 site of the cation-dependent mannose 6-phosphate receptor (CD-MPR) but not its phosphorylation is required for GGA1 and AP-1 binding.PMID 15044437Read ↗

Interaction of the cation-dependent mannose 6-phosphate receptor with GGA proteins.Semantic proximity Read ↗

Binding of GGA2 to the lysosomal enzyme sorting motif of the mannose 6-phosphate receptor.Semantic proximity Read ↗

Cooperation of GGAs and AP-1 in packaging MPRs at the trans-Golgi network.Semantic proximity Read ↗

GGA1 interacts with the adaptor protein AP-1 through a WNSF sequence in its hinge region.Semantic proximity Read ↗

Multiple phosphorylation events regulate the subcellular localization of GGA1.Semantic proximity Read ↗

Sorting of mannose 6-phosphate receptors mediated by the GGAs.Semantic proximity Read ↗

Phosphorylation-induced conformational changes regulate GGAs 1 and 3 function at the trans-Golgi network.Semantic proximity Read ↗

EpsinR: an AP1/clathrin interacting protein involved in vesicle trafficking.Semantic proximity Read ↗

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The palmitoyltransferase of the cation-dependent mannose 6-phosphate receptor cycles between the plasma membrane and endosomes.Semantic proximity Read ↗

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