Article
Identification of a site in Sar1 involved in the interaction with the cytoplasmic tail of glycolipid glycosyltransferases.
The Journal of biological chemistry - 24 Sept 2010
Quintero Cristián A, Giraudo Claudio G, Villarreal Marcos, Montich Guillermo, Maccioni Hugo J F
Abstract excerpt
Glycolipid glycosyltransferases (GGT) are transported from the endoplasmic reticulum (ER) to the Golgi, their site of residence, via COPII vesicles. An interaction of a (R/K)X(R/K) motif at their cytoplasmic tail (CT) with Sar1 is critical for the selective concentration in the transport vesicles. In this work using computational docking, we identify three putative binding pockets in Sar1 (sites A, B, and C)...
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