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Article

Phosphorylation-induced conformational changes regulate GGAs 1 and 3 function at the trans-Golgi network.

The Journal of biological chemistry - 18 Apr 2003

Ghosh Pradipta, Kornfeld Stuart

Abstract excerpt

The GGAs (Golgi-localizing, gamma-adaptin ear homology domain, ARF-binding) are a family of multidomain proteins implicated in protein trafficking between the Golgi and the endosomes. All three GGAs (1, 2, and 3) bind to the mannose 6-phosphate receptor tail via their VHS domains, as well as to the adaptor protein complex-1 via their hinge domains. The latter interaction has been proposed to be important for...

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Source

Identifiers

PMID: 12578827
DOI: 10.1074/jbc.M212543200

Genes

GGA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Phosphorylation-induced conformational changes regulate GGAs 1 and 3 function at the trans-Golgi network.PMID 12578827Read ↗

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